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Tue, 10/22/2019 - 14:50
- Mechanisms and functions of ATP-dependent chromatin remodeling complexes and their place in genome regulation.
- The study of the structural differences between members of large metalloenzyme superfamilies that share common features but promote different reactions or use distinct cofactors.
J. Martin Bollinger, Jr.
- The understanding of the relationship between the structures and catalytic mechanisms of enzymes that employ such clusters, and to elucidate the biochemical mechanisms by which the proteins acquire their clusters.
- Elucidating the chemical mechanisms by which enzymes containing iron-sulfur clusters catalyze chemical reactions.
- Genomics, structural and functional relationships, metabolism, physiology and ecology of chlorophototrophic bacteria.
- The study the enzymology and molecular biology of anaerobic microbes from the Archaea domain.
- Biophysical studies of electron transfer mechanisms in photosynthetic prokaryotes.
- A structural approach to learn more about viral infectivity, tropism, evolution and pathogenicity
- The understanding of the molecular mechanisms involved in the replication and assembly of flaviviruses and alphaviruses.
- Structural biology of catalytic ribonucleoprotein complexes.
- The coupling of molecular parasitology and structural biology to study the malaria parasite.
- We apply cryo-EM and X-ray crystallography techniques to reveal three-dimensional structures of DNA and RNA polymerases for elucidating the mechanisms of DNA replication and RNA transcription.
- The use of solution nuclear magnetic resonance (NMR) spectroscopy, in combination with thermodynamic analysis, chemical biology, and cellular assays to advance understanding of protein function.
- The understanding of how genes are regulated by combining genetic, biochemical and structural descriptions
- The understanding of how the globin coupled sensor protein family senses oxygen and transmits the binding signal into downstream events
- Elucidating molecular structures relevant to chemists, biochemists, material scientists etc. and educating graduate students embarking in these fields, the technique of X-ray diffraction (crystal growth, data collection and structure solution and refinement, and interpretation).