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Structural Biology

Jean-Paul Armache

  • Mechanisms and functions of ATP-dependent chromatin remodeling complexes and their place in genome regulation. 

Amie Boal

  • The study of the structural differences between members of large metalloenzyme superfamilies that share common features but promote different reactions or use distinct cofactors.

J. Martin Bollinger, Jr.

  • The understanding of the relationship between the structures and catalytic mechanisms of enzymes that employ such clusters, and to elucidate the biochemical mechanisms by which the proteins acquire their clusters.

Squire Booker

  • Elucidating the chemical mechanisms by which enzymes containing iron-sulfur clusters catalyze chemical reactions.

Donald Bryant

  • Genomics, structural and functional relationships, metabolism, physiology and ecology of chlorophototrophic bacteria.

James Ferry

  • The study the enzymology and molecular biology of anaerobic microbes from the Archaea domain.

John Golbeck

  • Biophysical studies of electron transfer mechanisms in photosynthetic prokaryotes.

Susan Hafenstein

  • A structural approach to learn more about viral infectivity, tropism, evolution and pathogenicity

Joyce Jose

  • The understanding of the molecular mechanisms involved in the replication and assembly of flaviviruses and alphaviruses.

Andrey Krasilnikov

  • Structural biology of catalytic ribonucleoprotein complexes.

Scott Lindner

  • The coupling of molecular parasitology and structural biology to study the malaria parasite.

Katsuhiko Murakami

  • We apply cryo-EM and X-ray crystallography techniques to reveal three-dimensional structures of DNA and RNA polymerases for elucidating the mechanisms of DNA replication and RNA transcription.

Tracy Nixon

Scott Showalter

  • The use of solution nuclear magnetic resonance (NMR) spectroscopy, in combination with thermodynamic analysis, chemical biology, and cellular assays to advance understanding of protein function.

Song Tan

  • The understanding of how genes are regulated by combining genetic, biochemical and structural descriptions

Emily Weinert

  • The understanding of how the globin coupled sensor protein family senses oxygen and transmits the binding signal into downstream events

Hemant Yennawar

  • Elucidating molecular structures relevant to chemists, biochemists, material scientists etc. and educating graduate students embarking in these fields, the technique of X-ray diffraction (crystal growth, data collection and structure solution and refinement, and interpretation).