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Research
Biochemistry and Enzymology

Jean-Paul Armache

  • Mechanisms and functions of ATP-dependent chromatin remodeling complexes and their place in genome regulation. 

Lu Bai

  • Chromatin structure and its role in gene regulation.

Philip Bevilacqua

  • Attaining a molecular level understanding of RNA in biology.

Amie Boal

  • The study of the structural differences between members of large metalloenzyme superfamilies that share common features but promote different reactions or use distinct cofactors.

J. Martin Bollinger, Jr.

  • The understanding of the relationship between the structures and catalytic mechanisms of enzymes that employ such clusters, and to elucidate the biochemical mechanisms by which the proteins acquire their clusters.

Squire Booker

  • Elucidating the chemical mechanisms by which enzymes containing iron-sulfur clusters catalyze chemical reactions.

Donald Bryant

  • Genomics, structural and functional relationships, metabolism, physiology and ecology of chlorophototrophic bacteria.

James Ferry

  • The study the enzymology and molecular biology of anaerobic microbes from the Archaea domain.

John Golbeck

  • Biophysical studies of electron transfer mechanisms in photosynthetic prokaryotes.

Ying Gu

  • The utilization of biochemical, molecular genetics, and spectroscopic approaches to decipher mechanisms of cellulose biosynthesis.

Wendy Hanna-Rose

  • We use genetic and metabolomics approaches in C. elegans to model inborn errors of metabolism and probe the molecular links between metabolic perturbations and animal behavior and physiology.

Kenneth Keiler

  • Protein quality control, ribosome rescue, and new antibiotics.

Carsten Krebs

  • The elucidation of the reaction mechanisms by which mono- and dinuclear non-heme-iron enzymes activate dioxygen (O2) for a wide variety of oxidative transformations.

Zhi-Chun Lai

  • Growth Control and Cancer Genetics

Arthur Lesk

  • Computational analysis of protein structure, function, genomics and evolution.

Manuel Llinás

  • The combination of tools from functional genomics, molecular biology, computational biology, biochemistry, and metabolomics to understand the fundamental molecular mechanisms underlying the development of this parasite

Timothy Meredith

Katsuhiko Murakami

  • We apply cryo-EM and X-ray crystallography techniques to reveal three-dimensional structures of DNA and RNA polymerases for elucidating the mechanisms of DNA replication and RNA transcription.

Denise Okafor

  • The structural mechanisms of signaling and regulation in protein complexes.

Andrew Patterson

  • understanding the host-metabolite-microbiota communication network‚ specifically how the manipulation of gut microbiota by diet and/or xenobiotics impacts host metabolites (e.g., bile acids, short chain fatty acids), their metabolism, and how these co-metabolites interact with host ligand-activated transcription factors

Gary Perdew

  •  The biochemical pathway of AHR activation and characterized species difference in AHR mediated transcriptional activation of target genes.

Jeffrey Peters

  • The role of the peroxisome proliferator-activated receptors (PPARs) in the regulation of homeostasis, toxicology and carcinogenesis.

Frank Pugh

  • Genomic mechanisms of eukaryotic gene regulation.

Joseph Reese

  • Stress-induced gene expression and UV resistance pathways, Regulation of mRNAs from birth to death during stress responses, Targeted protein degradation during transcriptional stress and How RNA Polymerase II contends with barriers throughout the genome.

Reena Roy

  • Forensic DNA analysis using massively parallel sequencing and short tandem repeat technology, trace evidence, fingerprints.

Scott Showalter

  • The use of solution nuclear magnetic resonance (NMR) spectroscopy, in combination with thermodynamic analysis, chemical biology, and cellular assays to advance understanding of protein function.

Moriah Szpara

  • Understanding the consequences of HSV latency for the neurons that harbor the HSV pathogen and the search for improved therapeutics using a combination of virology, neurobiology, next generation sequencing technologies, and bioinformatics.

Song Tan

  • The understanding of how genes are regulated by combining genetic, biochemical and structural descriptions

Ming Tien

Emily Weinert

  • The understanding of how the globin coupled sensor protein family senses oxygen and transmits the binding signal into downstream events

Xin Zhang