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Gene Regulation

Jean-Paul Armache

  • Mechanisms and functions of ATP-dependent chromatin remodeling complexes and their place in genome regulation. 

Lu Bai

  • Chromatin structure and its role in gene regulation.

James Ferry

  • The study the enzymology and molecular biology of anaerobic microbes from the Archaea domain.

David Gilmour

  • We use Drosophila as a model system for employing a multifaceted approach to study mechanisms of transcriptional regulation.

Ying Gu

  • The utilization of biochemical, molecular genetics, and spectroscopic approaches to decipher mechanisms of cellulose biosynthesis.

Ross Hardison

  • Epigenetic and genomic approaches for the systematic study of eukaryotic gene regulation

Kenneth Keiler

  • Protein quality control, ribosome rescue, and new antibiotics.

Zhi-Chun Lai

  • Growth Control and Cancer Genetics

Scott Lindner

  • The coupling of molecular parasitology and structural biology to study the malaria parasite.

Manuel Llinás

  • The combination of tools from functional genomics, molecular biology, computational biology, biochemistry, and metabolomics to understand the fundamental molecular mechanisms underlying the development of this parasite.

Shaun Mahony

  • We build machine learning applications to understand how transcription factors control cellular identity

Timothy Miyashiro

  • We use microbial genetics, biochemistry, and cell biology approaches to determine the molecular mechanisms that enable bacteria to establish symbiosis with a eukaryotic host.  The model system is the symbiosis formed between the bioluminescent bacterium Vibrio fischeri and the Hawaiian bobtail squid Euprymna scolopes.  Our primary interests in this system include quorum sensing, contact-dependent killing mechanisms, and sulfur metabolism.

Katsuhiko Murakami

  • We apply cryo-EM and X-ray crystallography techniques to reveal three-dimensional structures of DNA and RNA polymerases for elucidating the mechanisms of DNA replication and RNA transcription.

Denise Okafor

  • The structural mechanisms of signaling and regulation in protein complexes.

Robert Paulson

  • The mechanism of tissue regeneration using the response to anemia as a model system.

Gary Perdew

  • The biochemical pathway of AHR activation and characterized species difference in AHR mediated transcriptional activation of target genes.

Jeffrey Peters

  • The role of the peroxisome proliferator-activated receptors (PPARs) in the regulation of homeostasis, toxicology and carcinogenesis.

Frank Pugh

  • Genomic mechanisms of eukaryotic gene regulation.

Joseph Reese

  • Stress-induced gene expression and UV resistance pathways, Regulation of mRNAs from birth to death during stress responses, Targeted protein degradation during transcriptional stress and How RNA Polymerase II contends with barriers throughout the genome.

Scott Showalter

  • The use of solution nuclear magnetic resonance (NMR) spectroscopy, in combination with thermodynamic analysis, chemical biology, and cellular assays to advance understanding of protein function.

Song Tan

  • The understanding of how genes are regulated by combining genetic, biochemical and structural descriptions