Department of University Committees
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Peer Teaching Evaluation
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Curricular Affairs and Assessment
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Commencement
Program or Departmental Affiliations
The BMMB Graduate Program |
Centers
The Center for RNA Biology |
Research Interest
Structural biology of RNA and RNA-protein complexes
Honors and Awards
1991 |
Degree Cum Laude, Moscow Institute of Physics and Technology |
1995 |
Russian State Fellowship for Young Scientists, The Government of Russian Federation |
2002 |
National Research Service Award, National Institutes of Health |
2006 |
Beckman Young Investigator Award, Beckman Foundation |
2007 |
Basil O’Connor Scholar Research Award, March of Dimes Foundation (declined) |
2007 |
National Scientist Development Grant, American Heart Association |
2016 |
Daniel R. Tershak Award for Excellence in Teaching, Penn State University |
Selected Publications
- Perederina A, Li D, Lee H, Bator C, Berezin I, Hafenstein SL, Krasilnikov AS (2020). Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP. Nature Communications 11: 3474.
- Perederina A, Berezin I, Krasilnikov AS (2018). In vitro reconstitution and analysis of eukaryotic RNase P RNPs. Nucleic Acids Research 46: 6857-6868.
- Gopalan V, Jarrous N, Krasilnikov AS (2018). Change and necessity in the evolution of RNase P. RNA 24: 1-5.
- Lemieux B, Laterreur N, Perederina A, Noel J-F, Dubois M-L, Krasilnikov AS, Wellinger RJ (2016). Active yeast telomerase shares subunits with ribonucleoproteins RNase P and RNase MRP. Cell 165: 1171-1181.
- Fagerlund RD, Perederina A, Berezin I, Krasilnikov AS (2015). Footprinting analysis of interactions between the largest eukaryotic RNase P/MRP protein Pop1 and RNase P/MRP RNA components. RNA21: 1591-1605.
- Krasilnikov AS (2014). Applying UV-crosslinking to study RNA-protein interactions in multicomponent ribonucleoprotein complexes. Methods Mol. Biol. 1086: 193-207.
- Esakova O, Perederina A, Berezin I, Krasilnikov AS (2013). Conserved regions of ribonucleoprotein ribonuclease MRP are involved in interactions with its substrate. Nucleic Acids Research 41: 7084-7091.
- Khanova E, Esakova O, Perederina A, Berezin I, Krasilnikov AS (2012). Structural organizations of yeast RNase P and RNase MRP holoenzymes as revealed by UV-crosslinking studies of RNA-protein interactions. RNA 18: 720-728.
- Perederina A, Krasilnikov AS (2012). Crystallization of RNA-protein complexes: from synthesis and purification of individual components to crystals. Methods Mol. Biol. 905: 123-143.
- Perederina A, Khanova E, Quan C, Berezin I, Esakova O, Krasilnikov AS (2011). Interactions of a Pop5/Rpp1 heterodimer with the catalytic domain of RNase MRP. RNA 17: 1922-1931.
- Krasilnikov AS (2011). Ribonucleoprotein ribonucleases P and MRP. In Ribonucleases (ed. Nicholson AW), pp 319-342. Springer, New York, NY, doi: 10.1007/978-3-642-21078-5_13
- Esakova O, Perederina A, Quan C, Berezin I, Krasilnikov AS (2011). Substrate recognition by ribonucleoprotein Ribonuclease MRP. RNA 17: 356-364.
- Esakova O, Krasilnikov AS (2010). Of proteins and RNA: the RNase P/MRP family. RNA 16: 1725-1747.
- Perederina A, Krasilnikov AS (2010). The P3 domain of eukaryotic RNases P/MRP: Making a protein-rich RNA-based enzyme. RNA Biology 7: 534-539.
- Perederina A, Esakova O, Quan, C, Khanova E, Krasilnikov AS (2010). Eukaryotic Ribonucleases P/MRP: the crystal structure of the P3 domain. EMBO J. 29: 761-769.
- Lu Q, Wierzbicki S, Krasilnikov AS, Schmitt ME (2010). Comparison of mitochondrial and nucleolar RNase MRP reveals identical RNA components with distinct enzymatic activities and protein components. RNA 16: 529-537.
- Perederina A, Esakova O, Quan C, Khanova E, Krasilnikov AS (2010). Crystallization and preliminary X-ray diffraction analysis of the P3 RNA domain of yeast Ribonuclease MRP in a complex with RNase P/ MRP protein components Pop6 and Pop7. Acta Crystallographica F66: 76-80.
- Esakova O, Perederina A, Quan C, Schmitt ME, Krasilnikov AS (2008). Footprinting analysis demonstrates extensive similarity between eukaryotic RNase P and RNase MRP holoenzymes. RNA14: 1558-1567.
- Perederina A, Esakova O, Koc H, Schmitt ME, Krasilnikov AS (2007). Specific binding of a Pop6/Pop7 heterodimer to the P3 stem of yeast RNase MRP and RNase P RNAs. RNA 13: 1648-1655.
- Baird NJ, Srividya N, Krasilnikov AS, Mondragon A, Sosnick TR, Pan T (2006). Structural basis for altering the stability of homologous RNAs from a mesophilic and a thermophilic bacterium. RNA 12: 598-606.
- Torres-Larios A, Swinger, KK, Krasilnikov AS, Pan T, Mondragon A (2005). Crystal structure of the RNA component of bacterial Ribonuclease P. Nature 437: 584-587.
- Krasilnikov AS, Xiao Y, Pan T, Mondragon A (2004). Basis for structural diversity in homologous RNAs. Science 306: 104-107.
- Krasilnikov AS, Mondragon A (2003). On the occurrence of the T-loop RNA folding motif in large RNA molecules. RNA 9:640-643.
- Krasilnikov AS, Yang XJ, Pan T, Mondragon A (2003). Crystal structure of the specificity domain of ribonuclease P. Nature 421: 760-764.