Amie Boal
Professional Appointments and Affiliations
Professor of Chemistry
Professor of Biochemistry and Molecular Biology
Nicholas and Gelsa Pelick Family Chair in Science
Office
326 Chemistry Building
University Park, PA 16802
Education
Ph.D. Chemistry, California Institute of Technology, 2008
B.A. Chemistry, Pomona College, 2002
Honors and Awards
Camille Dreyfus Teacher-Scholar Award, 2018
NIH Pathway to Independence Award, 2012
NIH Ruth L. Kirschstein NRSA Postdoctoral Fellowship, 2011-2012
American Cancer Society Postdoctoral Fellowship, 2010-2011
Selected Publications
Blaesi, E.J.*; Palowitch, G.M.*; Hu, K.*; Kim, A.J.; Rose, H.R.; Alapati, R.B.; Lougee, M.G.; Kee, H.J.; Taguchi, A.T.; Tan, K.O.; Griffin, R.G.; Krebs, C.; Matthews, M.L.; Silakov, A.; Bollinger, J.M., Jr.; Allen, B.D.; Boal, A.K. “Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical.” Proc. Natl. Acad. Sci. USA 2018, 115, 10022-10027.
Rose, H.R.*; Ghosh, M.K.*; Maggiolo, A.O.; Pollock, C.J.; Blaesi, E.J.; Hajj, V.; Wei, Y.; Rajakovich, L.J.; Chang, W.-c.; Han, Y.; Hajj, M.; Pandelia, M.-E.; Krebs, C.; Bollinger, J.M., Jr.; Boal, A.K. “Structural basis for superoxide activation of Flavobacterium johnsoniae class I ribonucleotide reductase and for radical initiation by its dimanganese cofactor.” Biochemistry 2018, 57, 2679-2693.
Mitchell, A.J.*; Dunham, N.P.*; Martinie, R.J.; Bergman, J.A.; Pollock, C.J.; Hu, K.; Allen, B.D.; Chang, W.-c.; Silakov, A.; Bollinger, J.M., Jr.; Krebs, C.; Boal, A.K. “Visualizing the reaction cycle in an iron(II) and 2-(oxo)-glutarate-dependent hydroxlase.” J. Am. Chem. Soc. 2017, 139, 13830-13836.
Mitchell, A.J.; Dunham, N.P.; Bergman, J.A.; Wang, B.; Chang, W.-c. Liu, X.; Boal, A.K. “Structure-guided engineering of a small-molecule aliphatic halogenase.” Biochemistry 2017, 56, 441-444.
Mitchell, A.J.; Zhu, Q.; Maggiolo, A.O.; Ananth, N.; Hillwig, M.L.; Liu, X.; Boal, A.K. “Structural basis for selective chlorination by iron- and 2-oxo-glutarate-dependent WelO5.” Nat. Chem. Biol. 2016, 12, 636-640.
Schwalm, E.L.*; Grove, T.L.*; Booker, S.J.; Boal, A.K. “Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA.” Science 2016, 352, 309-312.
Boal, A. K., Grove, T. L., McLaughlin, M. I., Yennawar, N. H., Booker, S. J., and Rosenzweig, A. C. Structural basis for methyl transfer by a radical SAM enzyme. Science, 2011, 332, 1089-1092.
Boal, A. K., Cotruvo, J. A., Jr., Stubbe, J., and Rosenzweig, A. C. Structural basis for activation of class Ib ribonucleotide reductase. Science, 2010, 329, 1526-1530.
Boal, A. K., and Rosenzweig, A. C. Crystal structures of cisplatin bound to a human copper chaperone. J. Am. Chem. Soc., 2009, 131, 14196-14197.
Boal, A. K., Genereux, J. C., Sontz, P. A., Gralnick, J. A., Newman, D. K., and Barton, J. K. Redox signaling between DNA repair proteins for efficient lesion detection. Proc. Natl. Acad. Sci. USA, 2009, 106, 15237-15242.