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Tue, 10/22/2019 - 15:04
- Eukaryotic transcriptional regulation
- The utilization of biochemical, molecular genetics, and spectroscopic approaches to decipher mechanisms of cellulose biosynthesis.
- We use genetic and metabolomics approaches in C. elegans to model inborn errors of metabolism and probe the molecular links between metabolic perturbations and animal behavior and physiology.
- The study of self-incompatibility (SI), a self/non-self recognition mechanism between pollen and pistils, which was first well documented by Charles Darwin in a monograph published in 1865.
- Growth Control and Cancer Genetics
- The coupling of molecular parasitology and structural biology to study the malaria parasite.
- Molecular and cellular mechanisms underlying neuropsychiatric disorders as well as mechanisms of antidepressant drug therapies.
- We use microbial genetics, biochemistry, and cell biology approaches to determine the molecular mechanisms that enable bacteria to establish symbiosis with a eukaryotic host. The model system is the symbiosis formed between the bioluminescent bacterium Vibrio fischeri and the Hawaiian bobtail squid Euprymna scolopes. Our primary interests in this system include quorum sensing, contact-dependent killing mechanisms, and sulfur metabolism.
- The mechanism of tissue regeneration using the response to anemia as a model system.
- Genomic mechanisms of eukaryotic gene regulation.
- The Rolls lab aims to understand how neurons generate axons and dendrites with different microtubule organization, and how neurons respond to injury. Current projects focus on mechanisms that control microtubule polarity and dynamics and mechanisms that promote neuronal regeneration.
- We study the signal transduction and vesicular trafficking processes that promote migration in epithelial cells. We seek to understand the role of these processes in normal homeostasis and in pathological processes.
- Nervous system development and molecular mechanisms of neurodegenerative disorders
- The use of solution nuclear magnetic resonance (NMR) spectroscopy, in combination with thermodynamic analysis, chemical biology, and cellular assays to advance understanding of protein function.
- Understanding the consequences of HSV latency for the neurons that harbor the HSV pathogen and the search for improved therapeutics using a combination of virology, neurobiology, next generation sequencing technologies, and bioinformatics.
- The role of the cortical actin cytoskeleton in cell polarity and morphogenesis.