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Research
Bioinformatics and Genomics

Jean-Paul Armache

  • Mechanisms and functions of ATP-dependent chromatin remodeling complexes and their place in genome regulation. 

Lu Bai

  • Chromatin structure and its role in gene regulation.

Donald Bryant

  • Genomics, structural and functional relationships, metabolism, physiology and ecology of chlorophototrophic bacteria.

James Ferry

  • The study the enzymology and molecular biology of anaerobic microbes from the Archaea domain.

Santhosh Girirajan

  • Genetics of neurodevelopmental disorders

Ross Hardison

  • Epigenetic and genomic approaches for the systematic study of eukaryotic gene regulation

Teh-hui Kao

  • We use Petunia inflata as a model to study biochemical, molecular, and structural bases of a self/non-self recognition mechanism between pollen and pistil adopted by flowering plants to prevent in breeding and promote outcrossing.  

Manuel Llinás

  • The combination of tools from functional genomics, molecular biology, computational biology, biochemistry, and metabolomics to understand the fundamental molecular mechanisms underlying the development of this parasite.

Arthur Lesk

  • Computational analysis of protein structure, function, genomics and evolution.

Shaun Mahony

  • We build machine learning applications to understand how transcription factors control cellular identity

Paul Medvedev

  • Developing computer science techniques for analysis of biological data and on answering fundamental biological questions using such methods.

Timothy Miyashiro

  • We use microbial genetics, biochemistry, and cell biology approaches to determine the molecular mechanisms that enable bacteria to establish symbiosis with a eukaryotic host.  The model system is the symbiosis formed between the bioluminescent bacterium Vibrio fischeri and the Hawaiian bobtail squid Euprymna scolopes.  Our primary interests in this system include quorum sensing, contact-dependent killing mechanisms, and sulfur metabolism.

Anton Nekrutenko

Andrew Patterson

  • Understanding the host-metabolite-microbiota communication network‚ specifically how the manipulation of gut microbiota by diet and/or xenobiotics impacts host metabolites (e.g., bile acids, short chain fatty acids), their metabolism, and how these co-metabolites interact with host ligand-activated transcription factors

Frank Pugh

  • Genomic mechanisms of eukaryotic gene regulation.

Reena Roy

  • Forensic DNA analysis using massively parallel sequencing and short tandem repeat technology, trace evidence, fingerprints.

Moriah Szpara

  • Understanding the consequences of HSV latency for the neurons that harbor the HSV pathogen and the search for improved therapeutics using a combination of virology, neurobiology, next generation sequencing technologies, and bioinformatics.