Ruobo Zhou
Professional Appointments and Affiliations
Assistant Professor of Chemistry
Office
305 Chemistry Building
Education
Post doc, Chemistry and Chemical Biology, Harvard University
Ph.D., Physics, University of Illinois at Urbana-Champaign
B.S., Applied Physics, University of Science and Technology of China
Honors and Awards
Life Sciences Research Foundation (LSRF) Postdoctoral Fellowship, 2014-2017 ($180,000 in total; Awarded nationally to ~25 from over 1000 candidates across a spectrum of fields in life sciences)
NSF Center for the Physics of Living Cells (CPLC) Fellowship, 2012
Chinese Government Award for Outstanding Self-Financed Students Studying Abroad, 2012
Yee Memorial Fellowship, College of Engineering, UIUC, 2010
I2CAM-FAPERJ Biological Physics Spring School Travel Award, 2008
Samsung Award, 2005
Outstanding Student Award (First Prize), USTC, 2002-2005
Selected Publications
R Zhou, B Han, C Xia, X Zhuang. “Membrane-associated periodic skeleton is a signaling platform for RTK transactivation in neurons.” Science 365, 929-934 (2019)
R Zhou (co-corresponding author), O Yang, AC Déclais et al. “Junction resolving enzymes use multivalency to keep the Holliday junction dynamic.” Nature Chemical Biology 15, 269-275 (2019)
Y Sigal, R Zhou, X Zhuang. “Visualizing and discovering cellular structures with super-resolution microscopy.” Science 361, 880-887 (2018)
B Han, R Zhou (co-first author, co-corresponding author), C Xia, X Zhuang, “Structural organization of the actin-spectrin–based membrane skeleton in dendrites and soma of neurons” PNAS 114,6678-6685 (2017)
J He, R Zhou (co-first author), Z Wu et al., “Prevalent presence of periodic actin–spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species.” PNAS 113, 6029-6034 (2016)
C Wang, B Han, R Zhou, X Zhuang. “Real-time imaging of translation on single mRNA transcripts in live cells.” Cell 165, 990-1001 (2016)
TTM Ngo, Q Zhang, R Zhou, JG Yodh and T Ha. “Asymmetric unwrapping of nucleosomes under tension directed by DNA local flexibility.” Cell 160, 1135-1144 (2015)
R Zhou, J Zhang, ML Bochman, VA Zakian and T Ha. “Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA.” eLife 3, e02190 (2014)
R Zhou, AG Kozlov, R Roy, J Zhang, S Korolev, TM Lohman and T Ha. “SSB functions as a sliding platform that migrates on DNA via reptation.” Cell 146, 222-232 (2011), selected as the Cell PaperFlick (video) of the issue (youtube)
R Zhou, S Kunzelmann, M Webb, T Ha. “Detecting intramolecular conformational dynamics of single molecules in short distance range with sub-nanometer sensitivity.” Nano Letters 11, 5482-5488 (2011)
C Grashoff , BD Hoffman, MD Brenner, R Zhou, M Parsons, MT Yang, M A. McLean, SG Sligar, CS Chen, T Ha and MA Schwartz. “Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics.” Nature 466, 263–266 (2010)
S Hohng, R Zhou, MK Nahas, J Yu, K Schulten, DMJ Lilley and T Ha. “Fluorescence-force spectroscopy maps two-dimensional reaction landscape of the Holliday junction.” Science 318, 279-283 (2007)