Ruobo Zhou
Professional Appointments and Affiliations
Assistant Professor of Chemistry, Eberly College of Science
Assistant Professor of Biochemistry and Molecular Biology, Eberly College of Science
Assistant Professor of Biomedical Engineering, College of Engineering
Molecular Cellular and Integrative Bio-Sciences graduate program, Huck Institutes of the Life Sciences
Bioinformatics and Genomics graduate program, Huck Institutes of the Life Sciences
Neuroscience graduate program, Huck Institutes of the Life Sciences
Integrative and Biomedical Physiology graduate program, Huck Institutes of the Life Sciences
Office
305 Chemistry Building
Education
Post doc, Chemistry and Chemical Biology, Harvard University
Ph.D., Physics, University of Illinois at Urbana-Champaign
B.S., Applied Physics, University of Science and Technology of China
Honors and Awards
2023, Scialog Fellow for Advancing Bioimaging
2021, NIH Maximizing Investigators' Research Award (MIRA)
2014-2017, Life Sciences Research Foundation (LSRF) Postdoctoral Fellowship
2012, NSF Center for the Physics of Living Cells (CPLC) Fellowship
2012, Chinese Government Award for Outstanding Self-Financed Students Studying Abroad
2010, Yee Memorial Fellowship
2008, I2CAM-FAPERJ Biological Physics Spring School Travel Award, 2008
2005, Samsung Award
Selected Publications (#: Corresponding author)
J Fei , R Zhou#. "Watching biomolecules stride in real time." Science 379, 986-987 (2023)
R Zhou#, B Han, R Nowak, Y Lu, E Heller, C Xia, AH Chishti, VM Fowler, X Zhuang. “Proteomic and functional analyses of the periodic membrane skeleton in neurons.”Nature Communications 13, 3196 (2022)
R Zhou, B Han, C Xia, X Zhuang. “Membrane-associated periodic skeleton is a signaling platform for RTK transactivation in neurons.” Science 365, 929-934 (2019)
R Zhou#, O Yang, AC Déclais, et al. “Junction resolving enzymes use multivalency to keep the Holliday junction dynamic.” Nature Chemical Biology 15, 269-275 (2019)
Y Sigal, R Zhou, X Zhuang. “Visualizing and discovering cellular structures with super-resolution microscopy.” Science 361, 880-887 (2018)
B Han, R Zhou# (co-first author), C Xia, X Zhuang, “Structural organization of the actin-spectrin–based membrane skeleton in dendrites and soma of neurons” PNAS 114,6678-6685 (2017)
J He, R Zhou (co-first author), Z Wu, et al., “Prevalent presence of periodic actin–spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species.” PNAS 113, 6029-6034 (2016)
C Wang, B Han, R Zhou, X Zhuang. “Real-time imaging of translation on single mRNA transcripts in live cells.” Cell 165, 990-1001 (2016)
TTM Ngo, Q Zhang, R Zhou, JG Yodh, T Ha. “Asymmetric unwrapping of nucleosomes under tension directed by DNA local flexibility.” Cell 160, 1135-1144 (2015)
R Zhou, J Zhang, ML Bochman, VA Zakian, T Ha. “Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA.” eLife 3, e02190 (2014)
R Zhou, AG Kozlov, R Roy, J Zhang, S Korolev, TM Lohman, T Ha. “SSB functions as a sliding platform that migrates on DNA via reptation.” Cell 146, 222-232 (2011), selected as the Cell PaperFlick (video) of the issue (youtube)
R Zhou, S Kunzelmann, M Webb, T Ha. “Detecting intramolecular conformational dynamics of single molecules in short distance range with sub-nanometer sensitivity.” Nano Letters 11, 5482-5488 (2011)
C Grashoff , BD Hoffman, MD Brenner, R Zhou, M Parsons, MT Yang, M A. McLean, SG Sligar, CS Chen, T Ha, MA Schwartz. “Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics.” Nature 466, 263–266 (2010)
S Hohng, R Zhou, MK Nahas, J Yu, K Schulten, DMJ Lilley, T Ha. “Fluorescence-force spectroscopy maps two-dimensional reaction landscape of the Holliday junction.” Science 318, 279-283 (2007)