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Andrew D.
Patterson
Professor of Molecular Toxicology, and Biochemistry and Molecular Biology
Andrew Patterson

About Me

Dr. Patterson is the Tombros Early Career Professor, Professor of Molecular Toxicology, and Professor of Biochemistry and Molecular Biology at the Pennsylvania State University, University Park, PA and is the Scientific Director of Metabolomics. He holds joint appointments in the Department of Veterinary and Biomedical Sciences and the Department of Biochemistry and Molecular Biology. He received his BS in Microbiology from the Pennsylvania State University and his PhD from the Graduate Partnerships Program between the National Cancer Institute and George Washington University. Dr. Patterson did his postdoctoral fellowship in the Lab of Metabolism under Dr. Frank J. Gonzalez. 

 

Program or Departmental Affiliations

BMMB Graduate Program Computational, Bioinformatics, and Statistics Bioinformatics and Genomics Molecular, Cellular, and Integrative Biosciences

 

Editorial Boards

Associate Editor - Toxicological Sciences

Associate Editor - Environmental Health Perspectives

 

 

Centers

Center for Molecular Toxicology and Carcinogenesis

Microbiome Center

 

 

Research Summary

Dr. Patterson and his students, postdocs, and collaborators focus on understanding the host-metabolite-microbiota communication network—specifically how the manipulation of gut microbiota by diet and/or xenobiotics impacts host metabolites (e.g., bile acids, short chain fatty acids), their metabolism, and how these co-metabolites interact with host ligand-activated transcription factors. The lab employs a variety of tools, including NMR- and mass spectrometry-based metabolomics, genomics, and conventional and gnotobiotic transgenic mice, to facilitate its study of these pathways and understand their impact on human health and disease.  

Dr. Patterson teaches VB SC 230: The Science of Poisons which serves as the introductory course for the Toxicology major, guiding students as they examine important principles, such as dose-response and routes and sites of exposure, as well as mechanisms of toxicity, including delivery, chemical interactions, and resultant toxicities.

 

 

Selected Publications

  1. L. Zhang, R.G. Nichols, J. Correll, I.A. Murray, N. Tanaka, P.B. Smith, T.D. Hubbard, A. Sebastian, I. Albert, E. Hatzakis, F.J. Gonzalez, G.H. Perdew, A.D. Patterson. Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation. Environ Health Perspect. 2015  Jul;123(7):679-88. doi: 10.1289/ehp.1409055. Epub 2015 Mar 13. PubMed PMID: 25768209; PubMed Central PMCID: PMC4492271.
     
  2. C. Jiang, C. Xie , Y Lv, J. Li, K.W. Krausz, J. Shi, C.N. Brocker, D. Desai, S.G. Amin, W.H. Bisson, Y. Liu, O. Gavrilova, A.D. Patterson, F.J. Gonzalez. Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nat Commun. 2015 Dec 15;6:10166. doi: 10.1038/ncomms10166. PubMed PMID: 26670557; PubMed Central PMCID: PMC4682112.
     
  3. L. Zhang, C. Xie, R.G. Nichols, S.H. Chan, C. Jiang, R. Hao, P.B. Smith, J. Cai, M.N. Simons, E. Hatzakis, C.D. Maranas, F.J. Gonzalez, A.D. Patterson. Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism. mSystems. 2016 Oct 11;1(5). pii: e00070-16. PubMed PMID: 27822554; PubMed Central PMCID: PMC5080402.
     
  4. J. Cai, J. Zhang, Y. Tian, L. Zhang, E. Hatzakis, K.W. Krausz, P.B. Smith, F.J. Gonzalez, A.D. Patterson. Orthogonal Comparison of GC-MS and (1)H NMR Spectroscopy for Short Chain Fatty Acid Quantitation. Anal Chem. 2017 Jun 26. doi:10.1021/acs.analchem.7b00848. [Epub ahead of print] PubMed PMID: 28650151.
     
  5. J. Cai, R.G. Nichols, I. Koo, Z.A. Kalikow, L. Zhang, Y. Tian, J. Zhang, P.B. Smith, A.D. Patterson. Multiplatform Physiologic and Metabolic Phenotyping Reveals Microbial Toxicity. mSystems. 2018 Nov 6;3(6). pii: e00123-18. doi: 10.1128/mSystems.00123-18. eCollection 2018 Nov-Dec. PubMed PMID: 30417115; PubMed Central PMCID: PMC6222046.. 
     
  6. L. Zhang, R.G. Nichols, A.D. Patterson. The aryl hydrocarbon receptor as a moderator of host-microbiota communication. Current Opinion in Toxicology. 2017;2(1):30-35. doi: 10.1016/j.cotox.2017.02.001. 
     
  7. Nichols RG, Peters JM, Patterson AD. Interplay Between the Host, the Human Microbiome, and Drug Metabolism. Hum Genomics. 2019 Jun 11;13(1):27. doi:10.1186/s40246-019-0211-9. Review. PubMed PMID: 31186074; PubMed Central PMCID: PMC6558703.