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Holly
Kleinschmidt
BMMB Graduate Student - Bai Lab
Image of Holly Kleinschmidt
The Bai Lab

About Me

In 2019, I obtained B.S. degrees in Biochemistry and Environmental Science from Saint Louis University in my hometown of Saint Louis, Missouri. I joined Penn State’s BMMB Ph.D. program in August 2019, and in January 2020, I was welcomed into Dr. Lu Bai’s lab. I currently serve as the president of the BMMB Graduate Student Association and as Public Relations Officer of Penn State’s Graduate Women in Science chapter. In my free time, I enjoy hiking, playing video games, reading, and cooking/baking. 

 

Research Interest

In Dr. Lu Bai’s lab, I study the epigenetic factors that influence transcription factor binding in mammalian cells. 

 

Research Summary

I am investigating the factors that influence pioneer transcription factor binding in mammalian cell lines using various approaches. Using a method developed by the lab called ChIP-ISO (Chromatin ImmunoPrecipitation using Integrated Synthetic Oligonucleotides), I am studying how chromatin environment, co-factor binding, motif strength, and other factors impact the binding of pioneer factors like FOXA1 in human cell cancer lines and OCT4 in human embryonic cell lines. I am also using computational methods to investigate transcription factor binding logic. 

 

Programs and Training Centers

  • The BMMB Graduate Program

 

Honors and Awards

  • ACS Junior in Chemistry Award
     
  • Michael D. Barber, S.J. Chemistry Scholarship Award
     
  • Homer F. Braddock and Nellie H. and Oscar L. Roberts Fellowship
     
  • Paul & Harriet Campbell Distinguished Graduate Fellowship
     
  • Science Achievement Rosalind E. Franklin Graduate Scholarship in BMB
     
  • Eukaryotic Gene Regulation (EGR) Predoctoral Training Program Trainee