A recent paper from the Lee group has been named an ACS Editors' Choice Article Publication. The paper, entitled “Physical Chemistry of Epigenetics: Single-Molecule Investigations” was authored by Professor of Chemistry Tae-Hee Lee.
It focuses on epigenetic DNA and histone protein modifications. Although the term epigenetics initially required inheritability, it now frequently includes noninherited histone modifications associated with gene regulation. Important epigenetic modifications for healthy cell growth and proliferation include DNA methylation, histone acetylation, methylation, phosphorylation, ubiquitination, and SUMOylation (SUMO = Small Ubiquitin-like Modifier). The Lee group found that these modifications induce changes in the structure and structural dynamics of the nucleosome and their thermodynamic and kinetic stabilities. Going forward, the group plans to continue studying the implications of these changes in gene regulation.
The selection of ACS Editors' Choice Articles is based on recommendations by the scientific editors of ACS journals from around the world. These peer-reviewed, open access articles consist of research that exemplifies the Society's commitment to improving people's lives through the transforming power of chemistry.