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David Nagib, The Ohio State University

Title: "Harnessing Radicals and Carbenes To Enable Unconventional Reactivity"

Abstract:

Radical and carbene chemistry can afford opposite or orthogonal reactivity to classic two-electron pathways. By developing radical chaperone strategies that merge open (1e-) and closed shell (2e-) processes, we have harnessed this complementary reactivity and imparted new types of chemo-, regio-, and stereo- selectivity for remote, double, or reversed C-H and C-O functionalizations of alcohols, amines, and carbonyls. These carbene and radical chaperone strategies are continually being developed to streamline the synthesis of complex, medicinally relevant molecules and heterocycles. This seminar will highlight our newest, most exciting chemistry and the mosaic of champions behind these discoveries.