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Biocatalysis and complex molecule synthesis
Add to Calendar 2023-04-20T18:30:00 2023-04-20T19:30:00 UTC Biocatalysis and complex molecule synthesis 301A Chemistry
Start DateThu, Apr 20, 2023
2:30 PM
End DateThu, Apr 20, 2023
3:30 PM
Presented By
Alison Narayan - University of Michigan, Ann Arbor
Event Series: Chemistry Department Biological Seminar Series Spring 2023
Alison Narayan

Alison Narayan - University of Michigan, Ann Arbor



Natural sources, such as plants, fungi and microbes, have historically provided compounds with potent pharmaceutical properties. While it can be challenging to build complex natural products in a lab using existing chemistry methods, Nature has perfected these biosynthetic pathways. The work described leverages the power of Nature’s tools for building complex molecules to synthesize novel molecules with therapeutic potential. The reactivity and selectivity of enzymes from natural product pathways are often unparalleled in existing chemical methods. Enzymes with potential synthetic utility are used as a starting point for engineering biocatalysts with (1) broad substrate scope, (2) high catalytic efficiency, and (3) exquisite site- and stereoselectivity. These biocatalytic methods are employed to efficiently synthesize biologically active complex molecules.