Erica Graff

Research Group

Cremer

Research

My work focuses on understanding the factors that drive the liquid-liquid phase separation of protein solutions. Liquid-liquid phase separation (LLPS) is the process by which a homogeneous solution spontaneously splits into two homogeneous phases. In the case of protein solutions, these two phases are a protein-rich phase that exists at the bottom of the container, and a protein-poor phase at the top. LLPS has implications in various fields ranging from understanding the origins of life in the presence of membraneless organelles to preventing reversible association within therapeutic antibody solutions.