Alexey Silakov
Professional Appointments and Affiliations
Associate Professor of Chemistry
Office
330 Chemistry Building
University Park, PA 16802
Mailing Address
104 Chemistry Building
Education
Ph.D., Physical Chemistry, Heinrich-Heine-Universität Düsseldorf/ Max-Planck Institute for Bioinorganic Chemistry, Germany, 2007
M.S., Physics, Kazan State University, Russia, 2003
Honors and Awards
NSF CAREER Award, 2020
John Weil Young Investigator Award, International EPR Society, 2011
58th Lindau Nobel Laureate Meeting, Physics, 2008
Selected Recent Publications
J Taylor, et al. A [FeFe] Hydrogenase–Rubrerythrin Chimeric Enzyme Functions to Couple H2 Oxidation to Reduction of H2O2 in the Foodborne Pathogen Clostridium perfringens
Journal of the American Chemical Society, 2025, 147, 11, 9764–9773 https://doi.org/10.1021/jacs.4c18425
RJ Martinie, et al. Structural Elucidation of the Reduced Mn(III)/Fe(III) Intermediate of the Radical-Initiating Metallocofactor in Chlamydia trachomatis Ribonucleotide Reductase
Biochemistry, 2025, 64 (5), 1157-1167 https://doi.org/10.1021/acs.biochem.4c00692
TD Rumbaugh, et al. Light-induced H2 generation in a photosystem I-O2-tolerant [FeFe] hydrogenase nanoconstruct
Proceedings of the National Academy of Sciences, 2024, 121 (34), e2400267121 https://doi.org/10.1073/pnas.2400267121
ES Wenger, et al. Optimized Substrate Positioning Enables Switches in the C–H Cleavage Site and Reaction Outcome in the Hydroxylation–Epoxidation Sequence Catalyzed by Hyoscyamine 6β-Hydroxylase
Journal of the American Chemical Society, 2024, 146 (35), 24271-24287 https://doi.org/10.1021/jacs.4c04406
JW Slater, et al. Synergistic Binding of the Halide and Cationic Prime Substrate of l-Lysine 4-Chlorinase, BesD, in Both Ferrous and Ferryl States
Biochemistry, 2023, 62 (16), 2480-2491 https://doi.org/10.1021/acs.biochem.3c00248
PS Corrigan, et al. Evidence of Atypical Structural Flexibility of the Active Site Surrounding of an [FeFe] Hydrogenase from Clostridium beijerinkii
Journal of the American Chemical Society, 2023, 145 (20), 11033-11044 https://doi.org/10.1021/jacs.2c13458
PS Corrigan, et al. Investigation of the Unusual Ability of the [FeFe] Hydrogenase from Clostridium beijerinckii to Access an O2-Protected State
Journal of the American Chemical Society, 2020, 142 (28), 12409-12419, https://doi.org/10.1021/jacs.0c04964