Carly Schissel
Awards and Honors
University of California–Berkeley Postdoc Achievement Award, 2024
American Chemical Society WCC Pfizer Emergent Leader Award, 2023
CAS Future Leaders Top 100 Award, 2023
National Science Foundation Graduate Research Fellowship (NSF GRFP), 2018-2021
MIT Department of Chemistry Award for Outstanding Teaching, 2016-2017
Education
Miller Institute Research Fellow, University of California–Berkeley, 2022-2025
Ph.D. in Chemistry, Massachusetts Institute of Technology, 2022
B.A. with Highest Honors in Chemistry, Williams College, 2016
Research
The Schissel Lab works at the intersection of chemistry and biology, focusing on the discovery, design, and synthesis of bioactive peptides with unusual amino acids and structures. By building upon nature’s blueprint, we aim to create novel peptides with therapeutic potential, leveraging chemical synthesis, molecular biology, and computational tools. Our research explores how these unusual structures can bestow new functions on peptides, ultimately pushing the boundaries of drug discovery and the understanding of bioactive molecules.
Schissel, C. K.; Roberts-Mataric, H.; Garcia, I.G.; Kang, H.; Mowzoon-Mogharrabi, R.; Francis, M. B.; Schepartz, A. Peptide Backbone Editing via Post-Translational O to C Acyl Shift J. Am. Chem. Soc. 2025 147(8), 6503-6513
Schissel, C. K.*; Farquhar, C. E.*; Malmberg, A. B.; Loas, A.; Pentelute, B. L. In-cell penetration selection—mass spectrometry produces noncanonical peptides for antisense delivery. ACS Chem Bio 2023, 18, 3, 615–628.
D’Angelo, K. A.; Schissel, C. K.; Pentelute, B. L.; Movassaghi, M. Total Synthesis of Himastatin. Science 2022, 375, 6583, 894-899.
Schissel, C.K.*; Mohapatra, S.*; Wolfe, J.M.; Fadzen, C.M.; Bellovoda, K.; Wu, C.-L.; Wood, J.A.; Malmberg, A.B.; Loas, A.; Gómez-Bombarelli, R.; Pentelute, B.L. Deep Learning to Design Nuclear-Targeting Abiotic Miniproteins. Nat. Chem. 2021, 13, 992-1000.
Lopez-Vidal, E. M.*; Schissel, C. K.*; Mohapatra, S.; Bellovoda, K.; Wu, C.-L.; Wood, J. A.;Malmberg, A. B.; Loas, A.; Gómez-Bombarelli, R.; Pentelute, B. L. Discovery of a Short Nuclear-Targeting Peptide for PMO Delivery using Machine Learning. JACS Au 2021, 1, 11, 2009-2020.
Hartrampf, N.; Saebi, A.*; Poskus, M.*; Gates, Z.P.; Callahan, A.J.; Cowfer, A.E.; Hanna, S.; Antilla, S.; Schissel, C.K.; Quartararo, A.J.; Ye, X.; Mijalis, A.J.; Simon, M.D.; Loas, A.; Liu, S.; Jessen, C.; Nielsen, T.E.; Pentelute, B.L. Synthesis of Proteins by Automated Flow Chemistry. Science 2020, 368, 6494, 980–987.