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First detailed picture of a cancer-related cell enzyme in action on a chromosome unit
First detailed picture of a cancer-related cell enzyme in action on a chromosome unit 29 October 2014A landmark study to be published in the October 30, 2014 print edition of the journal Nature provides new insight into the function of an enzyme related to the BRCA1 breast cancer protein. The study by a team at Penn State University is the first to produce a detailed working image of an enzyme in the Polycomb Repressive Complex 1 (PRC1) -- a group that regulates cell development and is associated with many types of cancer.
In Disease Outbreak Management, Flexibility Can Save Lives and Money
In Disease Outbreak Management, Flexibility Can Save  Lives and Money 21 October 2014A new approach for responding to and managing disease outbreaks is being proposed by a team of epidemiologists led by two Penn State University researchers. The team's flexible approach could save many lives and millions of dollars.
Greater Rates of Mitochondrial Mutations Discovered in Children Born to Older Mothers
Greater Rates of Mitochondrial Mutations Discovered in Children Born to Older Mothers 13 October 2014The discovery of a "maternal age effect" by a team of Penn State scientists that could be used to predict the accumulation of mitochondrial DNA mutations in maternal egg cells -- and the transmission of these mutations to children -- could provide valuable insights for genetic counseling. These mutations cause more than 200 diseases and contribute to others such as diabetes, cancer, Parkinson's disease, and Alzheimer's disease. The study found greater rates of the mitochondrial DNA variants in children born to older mothers, as well as in the mothers themselves. The research will be published in the early online edition of the Proceedings of the National Academy of Sciences on October 13, 2014.

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