Biochemistry, Biophysics, and Structual Biology
Ganesh Anand's Research Interest:
Uncovering dynamics of cellular macromolecular assemblies.
Jean-Paul Armache's Research Interest:
Mechanisms and functions of ATP-dependent chromatin
remodeling complexes and their place in genome regulation.
Philip Bevilacqua's Research Interest:
Attaining a molecular level understanding of RNA in biology.
Amie Boal's Research Interest:
The study of the structural differences between members
of large metalloenzyme superfamilies that share common
features but promote different reactions or use distinct cofactors
J. Martin Bollinger Jr.'s Research Interest:
The understanding of the relationship between the structures
and catalytic mechanisms of enzymes that employ such clusters,
and to elucidate the biochemical mechanisms by which the proteins
acquire their clusters.
Paul Cremer's Research Interest:
The exploitation of linear and non-linear vibrational
spectroscopies to follow the interactions of ions with
peptides, proteins, and macromolecules.
Marina Feric's Research Interest:
Biophysical mechanisms by which cells maintain their
organization over the course of aging.
Ying Gu's Research Interest:
The utilization of biochemical, molecular genetics, and
spectroscopic approaches to decipher mechanisms of
cellulose biosynthesis.
Wen Jiang's Research Interests:
Structural studies of amyloids, viruses, and protein complexes
using single particle cryo-EM; In situ structural biology with
correlative light/electron microscopy (CLEM), volume EM, and
electron tomography; Development of new methods to improve
cryo-EM sample grid preparations, data collections, image
analyses and 3D reconstructions.
Joyce Jose's Research Interest:
The understanding of the molecular mechanisms involved in the
replication and assembly of flaviviruses and alphaviruses.
Andrey Krasilnikov's Research Interest:
Structural biology of catalytic ribonucleoprotein complexes.
Carsten Krebs' Research Interest:
The elucidation of the reaction mechanisms by which mono-
and dinuclear non-heme-iron enzymes activate dioxygen (O2)
for a wide variety of oxidative transformations.
Arthur Lesk's Research Interest:
Computational analysis of protein structure, function,
genomics and evolution.
Scott E. Lindner's Research Interest:
The coupling of molecular parasitology and structural
biology to study the malaria parasite.
Timothy C. Meredith's Research Interest:
Bacterial cell envelope biosynthesis.
Katsuhiko Murakami's Research Interest:
We apply cryo-EM and X-ray crystallography techniques to reveal
three-dimensional structures of DNA and RNA polymerases for
elucidating the mechanisms of DNA replication and RNA transcription.
C. Denise Okafor's Research Interest:
The structural mechanisms of signaling and regulation
in protein complexes.
Andrew D. Patterson's Research Interest:
Understanding the host-metabolite-microbiota communication
network‚ specifically how the manipulation of gut microbiota by
diet and/or xenobiotics impacts host metabolites (e.g., bile acids,
short chain fatty acids), their metabolism, and how these co-metabolites
interact with host ligand-activated transcription factors.
Jeffrey Peter's Research Interest:
The role of the peroxisome proliferator-activated receptors (PPARs)
in the regulation of homeostasis, toxicology and carcinogenesis.
Joseph C. Reese's Research Interest:
Stress-induced gene expression and UV resistance pathways,
regulation of mRNAs from birth to death during stress responses,
targeted protein degradation during transcriptional stress and
how RNA Polymerase II contends with barriers throughout the genome.
Scott Showalter's Research Interest:
The use of solution nuclear magnetic resonance (NMR) spectroscopy,
in combination with thermodynamic analysis, chemical biology, and
cellular assays to advance understanding of protein function.
Song Tan's Research Interest:
The understanding of how genes are regulated by
combining genetic, biochemical and structural
descriptions.
Emily Weinert's Research Interest:
The understanding of how the globin coupled sensor protein
family senses oxygen and transmits the binding signal into
downstream events.
Hemant Yennewar's Research Interest:
Elucidating molecular structures relevant to chemists,
biochemists, material scientists etc. and educating graduate
students embarking in these fields, the technique of X-ray
diffraction (crystal growth, data collection and structure
solution and refinement, and interpretation).