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BMMB Graduate Program

Graduate Faculty


Jean-Paul Armache

  • Mechanisms and functions of ATP-dependent chromatin remodeling complexes and their place in genome regulation. 

Paul Babitzke

  • Regulation of gene expression by RNA structure and RNA-binding proteins.

Lu Bai

  • Chromatin structure and its role in gene regulation.

Philip Bevilacqua

  • Attaining a molecular level understanding of RNA in biology.

Amie Boal

  • The study of the structural differences between members of large metalloenzyme superfamilies that share common features but promote different reactions or use distinct cofactors.

Donald Bryant

  • Genomics, structural and functional relationships, metabolism, physiology and ecology of chlorophototrophic bacteria.

J. Martin Bollinger, Jr.

  • The understanding of the relationship between the structures and catalytic mechanisms of enzymes that employ such clusters, and to elucidate the biochemical mechanisms by which the proteins acquire their clusters.

Squire Booker

  • Elucidating the chemical mechanisms by which enzymes containing iron-sulfur clusters catalyze chemical reactions.

Paul Cremer

  • The exploitation of linear and non-linear vibrational spectroscopies to follow the interactions of ions with peptides, proteins, and macromolecules.

James Ferry

  • The study the enzymology and molecular biology of anaerobic microbes from the Archaea domain.

Santhosh Girirajan

  • Genetics of neurodevelopmental disorders.

John Golbeck

  • Biophysical studies of electron transfer mechanisms in photosynthetic prokaryotes.

David Gilmour

  • We use Drosophila as a model system for employing a multifaceted approach to study mechanisms of transcriptional regulation.

Ying Gu

  • The utilization of biochemical, molecular genetics, and spectroscopic approaches to decipher mechanisms of cellulose biosynthesis.

Wendy Hanna-Rose

  • We use genetic and metabolomics approaches in C. elegans to model inborn errors of metabolism and probe the molecular links between metabolic perturbations and animal behavior and physiology.

Ross Hardison

  • Epigenetic and genomic approaches for the systematic study of eukaryotic gene regulation.

Susan Hafenstein

  • A structural approach to learn more about viral infectivity, tropism, evolution and pathogenicity.

Joyce Jose

  • The understanding of the molecular mechanisms involved in the replication and assembly of flaviviruses and alphaviruses.

Teh-hui Kao

  • We use Petunia inflata as a model to study biochemical, molecular, and structural bases of a self/non-self recognition mechanism between pollen and pistil adopted by flowering plants to prevent in breeding and promote outcrossing.  

Kenneth Keiler

  • Protein quality control, ribosome rescue, and new antibiotics.

Andrey Krasilnikov

  • Structural biology of catalytic ribonucleoprotein complexes.

Carsten Krebs

  • The elucidation of the reaction mechanisms by which mono- and dinuclear non-heme-iron enzymes activate dioxygen (O2) for a wide variety of oxidative transformations.

Zhi-Chun Lai

  • Growth Control and Cancer Genetics

Arthur Lesk

  • Computational analysis of protein structure, function, genomics and evolution.

Scott Lindner

  • The coupling of molecular parasitology and structural biology to study the malaria parasite.

Manuel Llinás

  • The combination of tools from functional genomics, molecular biology, computational biology, biochemistry, and metabolomics to understand the fundamental molecular mechanisms underlying the development of this parasite.

Bernard Lüscher

  • Molecular and cellular mechanisms underlying neuropsychiatric disorders as well as mechanisms of antidepressant drug therapies.

Shaun Mahony

  • We build machine learning applications to understand how transcription factors control cellular identity.

Paul Medvedev

  • Developing computer science techniques for analysis of biological data and on answering fundamental biological questions using such methods.

Timothy Meredith

  • Bacterial cell envelope biosynthesis.

Timothy Miyashiro

  • We use microbial genetics, biochemistry, and cell biology approaches to determine the molecular mechanisms that enable bacteria to establish symbiosis with a eukaryotic host.  The model system is the symbiosis formed between the bioluminescent bacterium Vibrio fischeri and the Hawaiian bobtail squid Euprymna scolopes.  Our primary interests in this system include quorum sensing, contact-dependent killing mechanisms, and sulfur metabolism.

Katsuhiko Murakami

  • We apply cryo-EM and X-ray crystallography techniques to reveal three-dimensional structures of DNA and RNA polymerases for elucidating the mechanisms of DNA replication and RNA transcription.

Anton Nekrutenko

  • Visit my website to learn more about my research.

Tracy Nixon

Denise Okafor

  • The structural mechanisms of signaling and regulation in protein complexes.

Andrew Patterson

  • Understanding the host-metabolite-microbiota communication network‚ specifically how the manipulation of gut microbiota by diet and/or xenobiotics impacts host metabolites (e.g., bile acids, short chain fatty acids), their metabolism, and how these co-metabolites interact with host ligand-activated transcription factors.

Robert Paulson

  • The mechanism of tissue regeneration using the response to anemia as a model system.

Gary Perdew

  • The biochemical pathway of AHR activation and characterized species difference in AHR mediated transcriptional activation of target genes.

Jeffrey Peters

  • The role of the peroxisome proliferator-activated receptors (PPARs) in the regulation of homeostasis, toxicology and carcinogenesis.

Kathleen Postle

  • We use molecular biology approaches to study the intriguing TonB system in E. coli, a virulence factor for Gram-negative pathogens that uses energy from the inner membrane for active transport across the outer membrane.

Joseph Reese

  • Stress-induced gene expression and UV resistance pathways, Regulation of mRNAs from birth to death during stress responses, Targeted protein degradation during transcriptional stress and How RNA Polymerase II contends with barriers throughout the genome.

Melissa Rolls

  • The Rolls lab aims to understand how neurons generate axons and dendrites with different microtubule organization, and how neurons respond to injury. Current projects focus on mechanisms that control microtubule polarity and dynamics and mechanisms that promote neuronal regeneration.

Lorraine Santy

  • We study the signal transduction and vesicular trafficking processes that promote migration in epithelial cells.  We seek to understand the role of these processes in normal homeostasis and in pathological processes.

Scott Selleck

  • Nervous system development and molecular mechanisms of neurodegenerative disorders.

Scott Showalter

  • The use of solution nuclear magnetic resonance (NMR) spectroscopy, in combination with thermodynamic analysis, chemical biology, and cellular assays to advance understanding of protein function.

Moriah Szpara

  • Understanding the consequences of HSV latency for the neurons that harbor the HSV pathogen and the search for improved therapeutics using a combination of virology, neurobiology, next generation sequencing technologies, and bioinformatics.

Song Tan

  • The understanding of how genes are regulated by combining genetic, biochemical and structural descriptions.

Claire Thomas

  • The role of the cortical actin cytoskeleton in cell polarity and morphogenesis.

Ming Tien

Emily Weinert

  • The understanding of how the globin coupled sensor protein family senses oxygen and transmits the binding signal into downstream events.

Hemant Yennawar

  • Elucidating molecular structures relevant to chemists, biochemists, material scientists etc. and educating graduate students embarking in these fields, the technique of X-ray diffraction (crystal growth, data collection and structure solution and refinement, and interpretation).

Xin Zhang